2089314-57-6

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2089314-57-6 Structure

Identification	Back Directory
[Name] AOH1160
[CAS] 2089314-57-6
[Synonyms] AOH1160 1-Naphthalenecarboxamide, N-[2-oxo-2-[(2-phenoxyphenyl)amino]ethyl]-
[Molecular Formula] C25H20N2O3
[MDL Number] MFCD01275905
[MOL File] 2089314-57-6.mol
[Molecular Weight] 396.44

Chemical Properties	Back Directory
[Boiling point ] 681.5±40.0 °C(Predicted)
[density ] 1.270±0.06 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[form ] Solid
[pka] 12.77±0.70(Predicted)
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis[1].
[in vivo] AOH1160 (40 mg/kg, gavage once a day) can inhibit the growth of breast cancer and small cell lung cancer in mice^[1].
[References] [1] Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. DOI:10.1158/1078-0432.CCR-18-0592

Spectrum Detail	Back Directory
[Spectrum Detail] AOH1160(2089314-57-6)¹HNMR

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