| Identification | Back Directory | [Name]
Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) | [CAS]
209248-71-5 | [Synonyms]
Diprotin A TFA
Ile-Pro-Pro (TFA)
Diprotin A TFA (Ile-Pro-Pro (TFA))
Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) | [Molecular Formula]
C19H32F3N3O6 | [MDL Number]
MFCD00270878 | [MOL File]
209248-71-5.mol | [Molecular Weight]
455.48 |
| Hazard Information | Back Directory | [Uses]
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1]. | [in vivo]
In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. | [IC 50]
DPP-4 | [References]
[1] Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393. DOI:10.1038/srep29393 |
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