| Identification | Back Directory | [Name]
OKADAIC ACID SODIUM SALT | [CAS]
209266-80-8 | [Synonyms]
HALOCHONDRINE A
OKADAIC ACID SODIUM
OKADAIC ACID SODIUM SALT
HALOCHONDRINE A, SODIUM SALT
Okadaic acid sodium salt (high purity)
OKADAIC ACID SODIUM SALT, 98%, HIGH PURITY
9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIOFOLICIN
OKADAIC ACID SODIUM SALT, PROROCENTRUM CONCAVUM
9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIFOLICIN SODIUM
okadaic acid sodium salt from prorocentrum concavum
9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIFOLICIN, SODIUM SALT | [EINECS(EC#)]
606-670-6 | [Molecular Formula]
C44H67NaO13 | [MDL Number]
MFCD00210208 | [MOL File]
209266-80-8.mol | [Molecular Weight]
826.98 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white solid | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO or ethanol | [form ]
film
| [color ]
translucent
| [biological source]
plant (Prorocentrum concavum) | [Water Solubility ]
water: 1mg/mL
DMSO: 20mg/mL
ethanol: 20mg/mL | [InChIKey]
BYHIFOCTDVNQQT-GHIYGBLASA-M |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white solid | [Uses]
Potent inhibitor of serine/threonine-specific protein phosphatases 1 and 2A (PP1 and PP2A). Does not inhibit tyrosine or alkaline phosphatases | [Biochem/physiol Actions]
Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. | [in vivo]
Okadaic acid sodium can be used to induce Alzheimer's disease models[6].
Induction of alzheimer's disease model[6] Background
Okadaic acid sodium is a Ser/Thr phosphatase enzyme inhibitor that causes Tau hyperphosphorylation and induces the intracellular aggregation of neurofibrillary tangles.
Specific Modeling Methods
Mice: Wistar ? male ?-250-300 g
Administration: 100μg ? icv ? single dose
Modeling Indicators Molecular changes: Induced increases in pTauser396 in the hippocampus.
Correlated Product(s): / Opposite Product(s): / | [IC 50]
PP1: 15-50 nM (IC50); PP2A: 0.1-0.3 nM (IC50); PP3: 3.7-4 nM (IC50); PP4: 0.1 nM (IC50); PP5: 3.5 nM (IC50); PP2B: ~4000 nM (IC50); PP7: >1000 nM (IC50) | [storage]
Store at -20°C (desiccate) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25-38 | [Safety Statements ]
26-36/37-45 | [RIDADR ]
UN 3462 6.1/PG 1
| [WGK Germany ]
3
| [HazardClass ]
6.1 | [HS Code ]
29321900 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Skin Irrit. 2 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|