| Identification | Back Directory | [Name]
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) | [CAS]
2093152-79-3 | [Synonyms]
SUN 52793
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) | [Molecular Formula]
C40H78N4O16 | [MDL Number]
MFCD30723292 | [MOL File]
2093152-79-3.mol | [Molecular Weight]
871.065 |
| Hazard Information | Back Directory | [Description]
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a 3-arm PEG reagentr consisting of a terminal azide group and two t-butyl esters. The azide group enables PEGylation via Click Chemistry. The t-buty ester groups can be hydrolyzed under mild acidic conditions. | [Uses]
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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