| Identification | Back Directory | [Name]
OTS193320 | [CAS]
2093401-33-1 | [Synonyms]
OTS193320
cis-N1-(2-(5-Chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine
1,4-Cyclohexanediamine, N1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N4-[(4-nitrophenyl)methyl]-, cis- | [Molecular Formula]
C28H30ClN5O4 | [MOL File]
2093401-33-1.mol | [Molecular Weight]
536.02 |
| Hazard Information | Back Directory | [Uses]
OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (DOX; HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX[1]. | [IC 50]
SUV39H2/KMT1B | [References]
[1] Theodore Vougiouklakis, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831. DOI:10.18632/oncotarget.25806 |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-8447131 13564518121 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm |
|