| Identification | Back Directory | [Name]
1-Pentyl-3-(1-naphthoyl)indole | [CAS]
209414-07-3 | [Synonyms]
JWH-18
AM-678
JWH -018
JWH 018 (solution)
JWH-018 (Spice Cannabinoid)
JWH 018 (exempt preparation)
1-Pentyl-3-(1-naphthoyl)indole
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1-Pentyl-3-(1-naphthoyl)indole
JWH 018
1-Naphthyl-(1-pentylindol-3-yl)Methanone
Naphthalen-1-yl-(1-pentylindol-3-yl)Methanone
3-[(naphthalen-1-yl)carbonyl]-1-pentyl-1H-indole
Naphthalen-1-yl(1-Pentyl-1H-Indol-3-yl)Methanone
1-Naphthalenyl-(1-pentyl-1H-indol-3-yl)methanone
(1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone | [EINECS(EC#)]
200-659-6 | [Molecular Formula]
C24H23NO | [MDL Number]
MFCD11846245 | [MOL File]
209414-07-3.mol | [Molecular Weight]
341.45 |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
55-59°C | [Boiling point ]
534.2±23.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [Fp ]
9℃ | [storage temp. ]
Desiccate at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Methanol: 30 mg/ml | [form ]
A neat solid | [color ]
white to beige | [InChI]
1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3 | [InChIKey]
JDNLPKCAXICMBW-UHFFFAOYSA-N | [SMILES]
O=C(C1=CN(CCCCC)C2=C1C=CC=C2)C3=CC=CC4=C3C=CC=C4 |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Uses]
Analgesic Drug | [Uses]
JWH 018 is the 18th compound synthesized in a series of more than 470 analogs and metabolites of ?9-Tetrahydro- cannabinol (THC) (T293200), the active component of marijuana. JWH 018 acts as cannabinoid receptor.
Controlled substance.
| [Biological Activity]
Potent cannabinoid receptor agonist with mild selectivity for CB 2 (K i values are 2.94 and 9.0 nM for CB 2 and CB 1 receptors respectively). | [Description]
JWH 018 (CRM) (Item No. 27973) is a certified reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. JWH 018 (CRM) (Item No. 27973) is provided as a DEA exempt preparation. This product is intended for research and forensic applications. | [Definition]
ChEBI: JWH 018 is an indolecarboxamide. | [References]
[1] MARIE H DEVENTER. Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo-Pyridyl Synthetic Cannabinoid Receptor Agonist CH-FUBBMPDORA.[J]. Drug Testing and Analysis, 2025. DOI: 10.1002/dta.3854
[2] KATHARINA ELISABETH GRAFINGER. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays[J]. Drug Testing and Analysis, 2021, 13 7: 1412-1429. DOI: 10.1002/dta.3054
[3] ANNELIES CANNAERT. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA[J]. ACS Chemical Neuroscience, 2020, 11 24: 4434-4446. DOI: 10.1021/acschemneuro.0c00644 |
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