| Chemical Properties | Back Directory | [Boiling point ]
380.5±42.0 °C(Predicted) | [density ]
1.104±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: 5 mg/mL (23.01 mM); Ethanol: 2 mg/mL (9.21 mM) | [form ]
Oil | [pka]
-1.51±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
EN40 is a potent, selective, and covalent ligand which inhibits aldehyde dehydrogenase 3A1 (ALDH3A1), and impairs lung cancer pathogenicity. | [Uses]
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1] | [in vivo]
EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1]. | Animal Model: | SCID mice with A549 cells[1] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal injection; 50mg/kg; from 14 days; once per day | | Result: | Had strong anti-tumorigenic effects in tumor xenografts. |
| [References]
[1] Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol.?2018 Aug 17;13(8):1970-1977 DOI:10.1021/acschembio.8b00381 |
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