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209480-63-7

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209480-63-7 Structure

209480-63-7 Structure
IdentificationBack Directory
[Name]

4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
[CAS]

209480-63-7
[Synonyms]

SB258585HCl
SB 258585 hydrochlor
SB 258585 HYDROCHLORIDE
Benzenesulfonamide, 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-
4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
[Molecular Formula]

C18H22IN3O3S
[MDL Number]

MFCD06798382
[MOL File]

209480-63-7.mol
[Molecular Weight]

487.36
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMF: 15 mg/mL
DMSO: 20 mg/mL
Ethanol: 0.25 mg/mLPBS (pH 7.2): 10 mg/mL
[form ]

solid
[color ]

off-white
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

36/37/38-42/43
[Safety Statements ]

26-36/37-45
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SB 258585 is a selective and potent SR-6 and 5-HT6R antagonist.
[Biological Activity]

Potent and selective 5-HT 6 receptor antagonist (pK i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.
[References]

[1] WARREN D HIRST. Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue[J]. British Journal of Pharmacology, 2009, 130 7: 1597-1605. DOI: 10.1038/sj.bjp.0703458
[2] CAROL ROUTLEDGE. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist[J]. British Journal of Pharmacology, 2009, 130 7: 1606-1612. DOI: 10.1038/sj.bjp.0703457
[3] AYAKA TATARA. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2012, 38 2: Pages 252-259. DOI: 10.1016/j.pnpbp.2012.04.008
[4] FANNY DUHR. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth[J]. Nature chemical biology, 2014, 10 7: 590-597. DOI: 10.1038/nchembio.1547
[5] SAKI SHIMIZU. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice[J]. Journal of pharmacological sciences, 2015, 127 4: Pages 439-445. DOI: 10.1016/j.jphs.2015.03.004
Spectrum DetailBack Directory
[Spectrum Detail]

4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE(209480-63-7)1HNMR
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