209480-63-7

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209480-63-7 Structure

Identification	Back Directory
[Name] 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
[CAS] 209480-63-7
[Synonyms] SB258585HCl SB 258585 hydrochlor SB 258585 HYDROCHLORIDE Benzenesulfonamide, 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]- 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE
[Molecular Formula] C18H22IN3O3S
[MDL Number] MFCD06798382
[MOL File] 209480-63-7.mol
[Molecular Weight] 487.36

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMF: 15 mg/mL DMSO: 20 mg/mL Ethanol: 0.25 mg/mLPBS (pH 7.2): 10 mg/mL
[form ] solid
[color ] off-white

Hazard Information	Back Directory
[Uses] SB 258585 is a selective and potent SR-6 and 5-HT6R antagonist.
[Biological Activity] Potent and selective 5-HT 6 receptor antagonist (pK i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.
[References] [1] WARREN D HIRST. Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue[J]. British Journal of Pharmacology, 2009, 130 7: 1597-1605. DOI: 10.1038/sj.bjp.0703458 [2] CAROL ROUTLEDGE. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist[J]. British Journal of Pharmacology, 2009, 130 7: 1606-1612. DOI: 10.1038/sj.bjp.0703457 [3] AYAKA TATARA. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2012, 38 2: Pages 252-259. DOI: 10.1016/j.pnpbp.2012.04.008 [4] FANNY DUHR. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth[J]. Nature chemical biology, 2014, 10 7: 590-597. DOI: 10.1038/nchembio.1547 [5] SAKI SHIMIZU. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice[J]. Journal of pharmacological sciences, 2015, 127 4: Pages 439-445. DOI: 10.1016/j.jphs.2015.03.004

Spectrum Detail	Back Directory
[Spectrum Detail] 4-IODO-N-[4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL]BENZENESULFONAMIDE HYDROCHLORIDE(209480-63-7)¹HNMR

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