| Identification | Back Directory | [Name]
1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]- | [CAS]
2095161-11-6 | [Synonyms]
1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]- | [Molecular Formula]
C26H34ClF3N4O4S | [MOL File]
2095161-11-6.mol | [Molecular Weight]
591.09 |
| Hazard Information | Back Directory | [Uses]
EPZ031686 is an potent and orally active SMYD3 inhibitor and with an IC50 value of 3 nM. EPZ031686 can be used for cancer research[1]. | [in vivo]
EPZ031686 (1-50 mg/mL; p.o. and i.v.; Male CD-1 mice) has good bioavailability following oral dosing in mice[1].
Pharmacokinetic Analysis in Male CD-1 mice[1]
| Route | Dose (mg/kg) | CL (mL/min/kg) | CLr (mL/min/kg) | Vss (L/kg) | tmax (h) | tmax (h) | Cmax (ng/mL) | AUClast (ng·h/mL) | AUCINF_obs (ng·h/mL) | | i.v. | 1 | 27 | 5.3 | 2.3 | 1.7 | / | / | 603 | 616 | | p.o. | 5 | / | / | / | 2.7/td>
| 0.89 | 345 | 1281 | 1479 | | p.o. | 50 | / | / | / | 2.2 | 1.3 | 4693 | 21158 | 21170 |
| [IC 50]
SMYD3: 3 nM (IC50) | [References]
[1] Mitchell LH, et, al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8. DOI:10.1021/acsmedchemlett.5b00272 |
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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