| Identification | Back Directory | [Name]
THZ1 Dihydrochloride | [CAS]
2095433-94-4 | [Synonyms]
THZ1 Dihydrochloride
(E)-THZ1 (dihydrochloride)
N-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide dihydrochloride | [Molecular Formula]
C31H29Cl2N7O2 | [MDL Number]
MFCD31536776 | [MOL File]
2095433-94-4.mol | [Molecular Weight]
602.52 |
| Chemical Properties | Back Directory | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO: 100 mg/mL (156.50 mM);Ethanol: Insoluble | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
(E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect[1][2]. | [storage]
Store at -20°C | [References]
[1] Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511(7511):616-620. DOI:10.1038/nature13393
[2] Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59(4):576-587. DOI:10.1016/j.molcel.2015.06.032 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
A.J Chemicals
|
| Tel: |
91-9810153283 |
| Website: |
www.ajchemicals.com |
|