| Identification | Back Directory | [Name]
Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester | [CAS]
2096984-25-5 | [Synonyms]
Lipid III-45
2-butyl-Octanoic acid 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester
Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester
9-[(9-[(2-butyloctanoyl)oxy]nonyl)(3-hydroxypropyl)amino]nonyl 2-butyloctanoate | [Molecular Formula]
C45H89NO5 | [MOL File]
2096984-25-5.mol | [Molecular Weight]
724.19 |
| Chemical Properties | Back Directory | [Boiling point ]
732.7±30.0 °C(Predicted) | [density ]
0.923±0.06 g/cm3(Predicted) | [solubility ]
Ethanol: 10 mg/ml | [pka]
14.99±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2,3 LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.1,2 LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.3WARNING This product is not for human or veterinary use. | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ARCHER D F. Delivery of therapeutic agents to the target tissue.[J]. Menopause: The Journal of The North American Menopause Society, 2011, 18 10: 1040-1041. DOI: 10.1097/gme.0b013e31822ff238
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
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| Company Name: |
Pharmalego
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| Tel: |
18321033991 |
| Website: |
https://cn.pharmalego.com/ |
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