| Identification | Back Directory | [Name]
T-1095 | [CAS]
209746-59-8 | [Synonyms]
T-1095
CS-2245
T 1095; T1095
T1095, T 1095, T1095
1-Propanone, 3-(5-benzofuranyl)-1-[2-hydroxy-6-[[6-O-(methoxycarbonyl)-β-D-glucopyranosyl]oxy]-4-methylphenyl]-
[(2R,3S,4S,5R,6S)-6-{2-[3-(1-benzofuran-5-yl)propanoyl]-3-hydroxy-5-methylphenoxy}-3,4,5-trihydroxyoxan-2-yl]methyl methyl carbonate | [Molecular Formula]
C26H28O11 | [MDL Number]
MFCD28404653 | [MOL File]
209746-59-8.mol | [Molecular Weight]
516.49 |
| Chemical Properties | Back Directory | [Boiling point ]
732.3±60.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
7.47±0.40(Predicted) | [Appearance]
light yellow solid |
| Hazard Information | Back Directory | [Uses]
T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 μM and 2.3 μM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research[1]. | [in vivo]
T-1095 is absorbed into the circulation via oral administration, is metabolized to the active form, T-1095A, and suppresses the activity of SGLTs in the kidney[1].
Orally administered T-1095 (3-30 mg/kg) increases urinary glucose excretion in diabetic animals, thereby decreasing blood glucose levels[1].
With long-term T-1095 (0.01% or 0.1% T-1095 mixed diet; for 28 days) treatment, both blood glucose and HbA1c levels were reduced in streptozotocin (STZ)-induced diabetic rats and yellow KK mice. In addition, there was amelioration of abnormal carbohydrate metabolism, i.e., hyperinsulinemia and hypertriglyceridemia, and of the development of microalbuminuria, in yellow KK mice[1]. | [IC 50]
hSGLT1: 22.8 μM (IC50); hSGLT2: 2.3 μM (IC50) | [References]
[1] A Oku, et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48(9):1794-800. DOI:10.2337/diabetes.48.9.1794 |
|
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|