| Hazard Information | Back Directory | [Uses]
Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins. | [IC 50]
ANGPTL3 | [References]
[1] Bergmark BA, Marston NA, Bramson CR, et al. Effect of Vupanorsen on Non-High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70.?Circulation. 2022;145(18):1377-1386. DOI:10.1161/CIRCULATIONAHA.122.059266
[2] Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, et al. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia.?Eur Heart J. 2020;41(40):3936-3945. DOI:10.1093/eurheartj/ehaa689 |
|
|