2097880-27-6

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2097880-27-6 Structure

Identification	Back Directory
[Name] GA001
[CAS] 2097880-27-6
[Synonyms] GA001 Benzamide, 3-bromo-N-[2-phenyl-1-(3-phenylpropyl)-1H-benzimidazol-5-yl]-
[Molecular Formula] C29H24BrN3O
[MOL File] 2097880-27-6.mol
[Molecular Weight] 510.42

Chemical Properties	Back Directory
[Melting point ] 220-224 °C
[density ] 1.321±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 12.530±0.43(predicted)

Hazard Information	Back Directory
[Uses] GA001 is a potent G9a antagonist, with an IC50 of 1.32 μM. GA001 induces autophagy and apoptosis that can be used for the breast cancer[1].
[References] [1] Zhang J, et al. Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells. Bioorg Chem. 2017 Jun;72:168-181. DOI:10.1016/j.bioorg.2017.04.005

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