| Identification | Back Directory | [Name]
TYK2-IN-2 | [CAS]
2098466-94-3 | [Synonyms]
TYK2-IN-2
TyK2 inhibitor 2
TyK2 IN 2,TyK-2-IN-2,TyK2IN2
Imidazo[1,2-b]pyridazine-3-carboxamide, 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)- | [Molecular Formula]
C16H18N6O | [MDL Number]
MFCD31544329 | [MOL File]
2098466-94-3.mol | [Molecular Weight]
310.35 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 25 mg/mL (80.55 mM) | [form ]
Solid | [pka]
12.63±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases[1]. | [IC 50]
Tyk2 JH2: 7 nM (IC50); PDE4: 62 nM (IC50) | [References]
[1] Moslin R, et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712. DOI:10.1039/c6md00560h |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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