| Identification | Back Directory | [Name]
TMEM16A Inhibitor C10bm | [CAS]
2098490-06-1 | [Synonyms]
TMEM16A Inhibitor C10bm
2-(2-Bromo-2,2-difluoroacetamido)-N-(o-tolyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
4H-Cyclohepta[b]thiophene-3-carboxamide, 2-[(2-bromo-2,2-difluoroacetyl)amino]-5,6,7,8-tetrahydro-N-(2-methylphenyl)- | [Molecular Formula]
C19H19BrF2N2O2S | [MOL File]
2098490-06-1.mol | [Molecular Weight]
457.33 |
| Hazard Information | Back Directory | [Uses]
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 μM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1]. | [References]
[1] Truong EC, et al., Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 Jun 8;60(11):4626-4635. DOI:10.1021/acs.jmedchem.7b00020 |
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