| Identification | Back Directory | [Name]
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [CAS]
2098799-78-9 | [Synonyms]
VHL ligand 7
VH 032, propargyl
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthia
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C27H34N4O5S | [MOL File]
2098799-78-9.mol | [Molecular Weight]
526.65 |
| Chemical Properties | Back Directory | [Boiling point ]
826.0±65.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.29±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
VH 032, propargyl is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development; incorporates an E3 ligase ligand with terminal propargyl ready for conjugation to a target protein ligand. | [IC 50]
VHL | [storage]
Store at -20°C | [References]
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
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