| Identification | Back Directory | [Name]
Alkyne-ethyl-PEG1-t-Butyl ester | [CAS]
2100306-55-4 | [Synonyms]
Alkyne-ethyl-PEG1-Boc Alkyne-ethyl-PEG1-t-Butyl ester | [Molecular Formula]
C11H18O3 | [MDL Number]
MFCD30723206 | [MOL File]
2100306-55-4.mol | [Molecular Weight]
198.26 |
| Hazard Information | Back Directory | [Description]
Alkyne-ethyl-PEG1-t-Butyl ester has an alkyne group and a t-butyl protected carboxyl group. The alkyne reacts with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. Thecarboxyl group group can be deprotected under mild acidic conditions. | [Uses]
Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkyne-ethyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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