| Identification | Back Directory | [Name]
N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) | [CAS]
2100306-69-0 | [Synonyms]
N-(PEG2-Boc)-N-bis(PEG2-propargyl)
N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl)
4,7,13,16-Tetraoxa-10-azanonadec-18-ynoic acid, 10-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C25H43NO8 | [MDL Number]
MFCD30723248 | [MOL File]
2100306-69-0.mol | [Molecular Weight]
485.61 |
| Chemical Properties | Back Directory | [Boiling point ]
531.2±45.0 °C(Predicted) | [density ]
1.060±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
6.88±0.50(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Description]
N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) is a multi-functional PEG linker with two terminal propargyl groups and a t-butyl ester. The propargyl groups enables formation of triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry. The t-butyl protected carboxyl group can be deprotected under mild acidic conditions. | [Uses]
N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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