| Identification | Back Directory | [Name]
Gboxin | [CAS]
2101315-36-8 | [Synonyms]
Gboxin
Gboxin chloride
2-ethyl-3-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-1-methyl-1H-benzo[d]imidazol-3-ium chloride | [Molecular Formula]
C22H33ClN2O2 | [MDL Number]
MFCD31813865 | [MOL File]
2101315-36-8.mol | [Molecular Weight]
392.97 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);25.45(Max Conc. mM)
DMSO:27.83(Max Conc. mg/mL);70.83(Max Conc. mM)
Ethanol:49.5(Max Conc. mg/mL);125.96(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);25.45(Max Conc. mM)
Water:6.0(Max Conc. mg/mL);15.27(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1]. | [References]
[1] Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346. DOI:10.1038/s41586-019-0993-x |
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