| Chemical Properties | Back Directory | [Boiling point ]
985.4±75.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.33±0.20(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2]. | [in vivo]
The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2]. Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2]. | [References]
[1] Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617. DOI:10.1021/acsmedchemlett.7b00154
[2] Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14. DOI:10.1016/j.gde.2006.12.009 |
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| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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