| Identification | Back Directory | [Name]
GNE-886 | [CAS]
2101957-05-3 | [Synonyms]
GNE-886
1H-Pyrrolo[2,3-c]pyridine-4-carboxamide, 6,7-dihydro-N-[1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl]-N-methyl-7-oxo-6-(2-propen-1-yl)- | [Molecular Formula]
C28H30N6O3 | [MDL Number]
MFCD31556840 | [MOL File]
2101957-05-3.mol | [Molecular Weight]
498.58 |
| Chemical Properties | Back Directory | [Boiling point ]
796.3±60.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.50±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 μM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 μM[1]. | [References]
[1] Crawford TD, et al. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Med Chem Lett. 2017 Jun 1;8(7):737-741. DOI:10.1021/acsmedchemlett.7b00132 |
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