| Identification | Back Directory | [Name]
1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl- | [CAS]
2102887-41-0 | [Synonyms]
1,6-Naphthyridine-6(5H)-ethanamine, 2-[[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzimidazol-6-yl)-5-fluoro-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl- | [Molecular Formula]
C27H30F2N8 | [MOL File]
2102887-41-0.mol | [Molecular Weight]
504.58 |
| Hazard Information | Back Directory | [Uses]
CDK4/6-IN-21 (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 has antitumor activity[1]. | [IC 50]
CDK4: 3.88 nM (IC50); CDK6: 3.31 nM (IC50) | [References]
[1] Guangxin Xia J, et al. Nitrogen-containing fused heterocyclic compound, as well as preparation method, intermediate, composition and application thereof. WO2017114512A1. 2017-07-06. |
|
|