| Identification | Back Directory | [Name]
3-Azabicyclo[3.2.1]octan-8-amine, 3-[3-(1H-indol-3-yl)-1-methylpropyl]-, (8-anti)- | [CAS]
2103079-87-2 | [Synonyms]
UHMCP1
3-Azabicyclo[3.2.1]octan-8-amine, 3-[3-(1H-indol-3-yl)-1-methylpropyl]-, (8-anti)- | [Molecular Formula]
C19H27N3 | [MOL File]
2103079-87-2.mol | [Molecular Weight]
297.44 |
| Hazard Information | Back Directory | [Uses]
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties[1]. | [References]
[1] Kobayashi A, et al. Identification of a small molecule splicing inhibitor targeting UHM domains. FEBS J. 2022 Feb;289(3):682-698. DOI:10.1111/febs.16199 |
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