| Identification | Back Directory | [Name]
L-Isoleucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester | [CAS]
210344-96-0 | [Synonyms]
L-Isoleucinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester | [Molecular Formula]
C31H45FN4O10 | [MOL File]
210344-96-0.mol | [Molecular Weight]
652.71 |
| Chemical Properties | Back Directory | [Boiling point ]
891.1±65.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.03±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis[1][2]. | [References]
[1] S-T Lee, et al. Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway. Br J Anaesth. 2009 Jan;102(1):80-9. DOI:10.1093/bja/aen322
[2] Philippe P Monnier, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011 Jul 20;31(29):10494-505. DOI:10.1523/JNEUROSCI.0148-11.2011 |
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