| Identification | Back Directory | [Name]
Z-LEHD-FMK | [CAS]
210345-04-3 | [Synonyms]
CS-1506
Z-LEHD-FMK
CASPASE-9 INHIBITOR
Z-LE(OME)HD(OME)-FMK
CASPASE-9 INHIBITOR I
Z-LEHD-FLUOROMETHYLKETONE
Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK
Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE)
Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate
Z-LE(OME)HD(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester | [Molecular Formula]
C32H43FN6O10 | [MDL Number]
MFCD01862609 | [MOL File]
210345-04-3.mol | [Molecular Weight]
690.73 |
| Chemical Properties | Back Directory | [Boiling point ]
1008.2±65.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO. | [form ]
powder
| [pka]
11.11±0.46(Predicted) | [color ]
White to yellow | [InChIKey]
YXRKBEPGVHOXSV-PPPRLRNRNA-N | [SMILES]
[C@H](C(=O)N[C@H](C(=O)CF)CC(=O)OC)(NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(C)C)NC(=O)OCC1C=CC=CC=1)CC1N=CNC=1 |&1:0,4,17,27,r| |
| Hazard Information | Back Directory | [Uses]
A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition | [Biological Activity]
Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo . | [in vivo]
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats[2]. | Animal Model: | Male Wistar albino rats (250-350 g) with SCI[2] | | Dosage: | 0.8 μmol/kg | | Administration: | I.v. for 1 or 7 days | | Result: | Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury. |
| [IC 50]
Caspase-9 | [storage]
Store at -20° C | [References]
[1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.
[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.
[3]. colak a, karao?lan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334. |
|
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|