| Identification | Back Directory | [Name]
2-(2-Heptyn-1-ylthio)phenol | [CAS]
210350-98-4 | [Synonyms]
2-(2-Heptyn-1-ylthio)phenol
Phenol, 2-(2-heptyn-1-ylthio)- | [Molecular Formula]
C13H16OS | [MDL Number]
MFCD20267410 | [MOL File]
210350-98-4.mol | [Molecular Weight]
220.33 |
| Hazard Information | Back Directory | [Uses]
2-(2-Heptyn-1-ylthio)phenol is an intermediate in the synthesis of 2-(2-Heptynylthio)phenol Acetate (H288500), which is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and COX-2, with IC50 values of 17 and 0.8uM for human recombinant COX-1 and COX-2 respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1. |
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