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QYL-685 is a Z-methenylcyclopropane nucleoside analog containing 2,6-diaminopurine, which has strong antiviral activity against HIV-1. QYL-685 showed activity against Zidovudine (HY-17413) resistant and Didanosine (HY-B0249) resistant HIV-1 infected clones in vitro. QYL-685 can be developed as a therapeutic drug for HIV-1 infection[1]. | [References]
[1] Uchida H, et al. In vitro anti-human immunodeficiency virus activities of Z-and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters[J]. Antimicrobial agents and chemotherapy, 1999, 43(6): 1487-1490. DOI:10.1128/AAC.43.6.1487 |
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