| Identification | Back Directory | [Name]
Benzenesulfonamide, N-[(1R,2R)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]-, rel- | [CAS]
2108567-79-7 | [Synonyms]
rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide
Benzenesulfonamide, N-[(1R,2R)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]-, rel- | [Molecular Formula]
C23H31N3O3S | [MDL Number]
MFCD32690912 | [MOL File]
2108567-79-7.mol | [Molecular Weight]
429.58 |
| Chemical Properties | Back Directory | [Boiling point ]
589.3±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.63±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM)[1][2][3]. | [IC 50]
TRPML1: 3.1 μM (IC50); TRPML2: 3.3 μM (EC50); TRPML3: 28.5 μM (IC50) | [References]
[1] Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313.??[Content Brief] DOI:10.1038/s41598-021-87817-4
[2] Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966. DOI:10.1016/j.ejmech.2020.112966
[3] Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20.??[Content Brief] DOI:10.1007/s00395-022-00930-x |
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