| Identification | Back Directory | [Name]
1,2-Benzenediol, 4-[(3S)-3-(acetyloxy)-7-phenylheptyl]-, 1,2-diacetate | [CAS]
2108714-20-9 | [Synonyms]
α7 nAchR-JAK2-STAT3 agonist 1
1,2-Benzenediol, 4-[(3S)-3-(acetyloxy)-7-phenylheptyl]-, 1,2-diacetate | [Molecular Formula]
C25H30O6 | [MOL File]
2108714-20-9.mol | [Molecular Weight]
426.5 |
| Hazard Information | Back Directory | [Uses]
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1]. | [References]
[1] Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811. DOI:10.1016/j.bmc.2022.116811 |
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| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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