| Identification | Back Directory | [Name]
INDOLE-7-BORONIC ACID | [CAS]
210889-31-9 | [Synonyms]
(1H-Indol-7-yl)
7-Borono-1H-Indole
INDOLE-7-BORONIC ACID
1H-indol-7-ylboronicaci
1H-Indole-7-boronic acid
1H-INDOL-7-YLBORONIC ACID
Boronicacid,B-1H-indol-7-yl- | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C8H8BNO2 | [MDL Number]
MFCD07787388 | [MOL File]
210889-31-9.mol | [Molecular Weight]
160.97 |
| Questions And Answer | Back Directory | [Synthesis]
In a light-protected flask, at 0°C and under an argon atmosphere, KH (62 mg, 1.53 mmol) was suspended in anhydrous THF (0.4 mL). 7-Bromoindole (300 mg, 1.53 mmol) in anhydrous THF (2.6 mL) was added, and the mixture was stirred for 15 minutes. After cooling to -78°C, a solution of tert-butyllithium in pentane (3.1 mmol), pre-cooled to -78°C, was added dropwise. The mixture was allowed to reach room temperature, stirred for 15 minutes, and then cooled again to -78°C. Add B(OMe)3 (341 μl, 1.53 mmol) and continue stirring at room temperature for 3 hours. Add H2O (5 ml) and extract the mixture with EtAcO (2 x 10 ml). Acidify the aqueous phase to pH 1 with 10% HCl and extract again with EtAcO (3 x 10 ml). Dry the combined organic extracts on anhydrous MgSO4 and filter. Evaporate the solvent, leaving crude indole-7-boronic acid in the form of a light brown oil. |
| Chemical Properties | Back Directory | [Boiling point ]
433.2±37.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [pka]
9.20±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
Indole-7-boronic Acid acts as a reagent in the preparation of pyridineamines with inhibitory and antitumor activities against small cell lung cancer. |
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