| Identification | Back Directory | [Name]
Benzonitrile, 2-amino-3-hydroxy- | [CAS]
211172-52-0 | [Synonyms]
2-AMino-3-hydroxy-benzonitrile
Benzonitrile, 2-amino-3-hydroxy- | [Molecular Formula]
C7H6N2O | [MDL Number]
MFCD11616259 | [MOL File]
211172-52-0.mol | [Molecular Weight]
134.14 |
| Chemical Properties | Back Directory | [Boiling point ]
301.5±37.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
8.37±0.10(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
B. 3-Hydroxy-2-nitrobenzonitrile (1.31 g) was mixed with 10% Pd/C (131 mg) in a solvent mixture of ethanol (9 mL) and ethyl acetate (18 mL), and the reaction was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through diatomaceous earth and the filtrate was subsequently concentrated. The resulting residue was purified by column chromatography (eluent: hexane/ethyl acetate, 6/4) to give 2-amino-3-hydroxybenzonitrile (398 mg, 37% yield). | [References]
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 6, p. 1319 - 1321
[2] Patent: WO2008/110793, 2008, A1. Location in patent: Page/Page column 106-107
[3] Patent: US5840764, 1998, A
[4] Patent: WO2011/106986, 2011, A1. Location in patent: Page/Page column 122; 123 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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