| Identification | Back Directory | [Name]
STAT5-IN-2 | [CAS]
2111834-61-6 | [Synonyms]
STAT5-IN-2
STAT5 inhibitor 17f
Quinoline, 1,2,3,4-tetrahydro-1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-(3-pyridinyl)- | [Molecular Formula]
C26 H27 N3 O | [MDL Number]
MFCD31813613 | [MOL File]
2111834-61-6.mol | [Molecular Weight]
397.51 |
| Chemical Properties | Back Directory | [Boiling point ]
635.5±55.0 °C(Predicted) | [density ]
1.160±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (251.57 mM; Need ultrasonic) | [form ]
Solid | [pka]
16.56±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect[1]. | [IC 50]
STAT5: 9 μM (EC50, in K562 cells); STAT5: 5 μM (EC50, in KU812 cells ) | [References]
[1] Ludovic Juen, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136. DOI:10.1021/acs.jmedchem.7b00369 |
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