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2111895-60-2

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2111895-60-2 Structure

2111895-60-2 Structure
IdentificationBack Directory
[Name]

Tos-PEG2-acid
[CAS]

2111895-60-2
[Synonyms]

Tos-PEG2-acid
3-(2-(Tosyloxy)ethoxy)propanoic acid
[Molecular Formula]

C12H16O6S
[MOL File]

2111895-60-2.mol
[Molecular Weight]

288.32
Chemical PropertiesBack Directory
[Boiling point ]

479.9±35.0 °C(Predicted)
[density ]

1.305±0.06 g/cm3(Predicted)
[pka]

4.25±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Tos-PEG2-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses]

Tos-PEG2-acid (compound 30) is a PEG linker containing a tosyl group and a terminal carboxylic acid. Tos-PEG2-acid can react with primary amine groups[1].
[References]

[1] Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198. DOI:10.1021/acs.jmedchem.4c00815
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