| Identification | Back Directory | [Name]
Methyltetrazine-amido-PEG7-azide | [CAS]
2112731-46-9 | [Synonyms]
Methyltetrazine-amido-PEG7-azide | [Molecular Formula]
C27H42N8O8 | [MDL Number]
MFCD30723245 | [MOL File]
2112731-46-9.mol | [Molecular Weight]
606.68 |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-amido-PEG7-azide is a bifunctional PEG crosslinker. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene) under miled condition, Azide(N3) group can enable copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. | [Uses]
Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-amido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|