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2112738-13-1

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2112738-13-1 Structure

2112738-13-1 Structure
IdentificationBack Directory
[Name]

Mal-amido-PEG2-Val-Cit-PAB-PNP
[CAS]

2112738-13-1
[Synonyms]

Mal-amido-PEG2-Val-Cit-PAB-PNP
[Molecular Formula]

C39H50N8O14
[MDL Number]

MFCD30828687
[MOL File]

2112738-13-1.mol
[Molecular Weight]

854.86
Chemical PropertiesBack Directory
[solubility ]

Soluble in DMSO, DCM, DMF
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker containing a maleimide group that can be reacted with thiol containing molecules.. The Val-Cit will specifically be cleaved by Cathepsin B.PNP can be substituted by nucleophiles.
[Biological Activity]

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker containing 2 units of PEG, which can be used to synthesize antibody drug conjugates (ADCs).
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

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