| Identification | Back Directory | [Name]
C16 PEG2 CERAMIDE | [CAS]
212116-78-4 | [Synonyms]
C16 PEG2 CERAMIDE
C16 PEG(2000) Ceramide
C16 PEG(5000) Ceramide
C16 PEG Ceramide, MW 750
N-PALMITOYL-SPHINGOSINE-1-[SUCCINYL(METHOXY POLYETHYLENE GLYCOL) 2000]
N-PALMITOYL-SPHINGOSINE-1-{SUCCINYL[METHOXY(POLYETHYLENE GLYCOL)750]};C16 PEG750 CERAMIDE
N-PALMITOYL-SPHINGOSINE-1-{SUCCINYL[METHOXY(POLYETHYLENE GLYCOL)2000]};C16 PEG2000 CERAMIDE
N-PALMITOYL-SPHINGOSINE-1-{SUCCINYL[METHOXY(POLYETHYLENE GLYCOL)5000]};C16 PEG5000 CERAMIDE | [Molecular Formula]
(C2H4O)nC39H73NO6 | [MDL Number]
MFCD02265697 | [MOL File]
212116-78-4.mol |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Methanol: Sparingly soluble: 1-10 mg/ml | [form ]
powder | [color ]
White to off-white | [SMILES]
O=C(CCC(OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
C16 PEG Ceramide, MW 750 is used for liposome preparation with NMR studies and PEGylated lipoplexes preparation. | [Uses]
C16 PEG5000 Ceramide might be used to stabilize nanosized bilayer disks and in the preparation of lipid aggregates. | [Uses]
C16 PEG750 Ceramide might be used as a control to test for nonspecific interactions during titrations of DNA-nanotube complexes with polyethylene glycol (PEG)-conjugated lipids. | [General Description]
Ceramide is a sphingolipid metabolite. The ceramides differ in their acyl chain length. | [Biochem/physiol Actions]
Therapeutic drugs enclosed in poly-ethylene glycol (PEG) conjugated ceramide serves as liposomal carriers, ensuring a longer circulation period. It exhibits a neutral surface electrostatic charge which prevents the leakage of positively charged encapsulated drug molecule. | [References]
[1] KENJI KUSUMOTO. Effect of the anchor in polyethylene glycol-lipids on the transfection activity of PEGylated cationic liposomes encapsulating DNA.[J]. Biological & pharmaceutical bulletin, 2012, 35 4: 445-448. DOI: 10.1248/bpb.35.445
[2] ALEKSANDRA M. URBANSKA . Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer[J]. Biomaterials, 2012, 33 18: Pages 4752-4761. DOI: 10.1016/j.biomaterials.2012.03.023
[3] LEE Y, JEONG M, LEE G, et al. Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics[J]. ACS Biomaterials Science & Engineering, 2024, 221 3. DOI: 10.34133/bmr.0017 |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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