| Identification | Back Directory | [Name]
9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID | [CAS]
212310-16-2 | [Synonyms]
CAY10408
HJVBXPOYFHMZAS-QTUFFCAPSA-N
9-OXO-11ALPHA,16R-DIHYDROXY-17-CYCLOBUTYL-5Z,13E-DIEN-1-OIC ACID
5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxocyclopentyl]-, (5Z)- | [Molecular Formula]
C23H36O5 | [MDL Number]
MFCD05865284 | [MOL File]
212310-16-2.mol | [Molecular Weight]
392.53 |
| Hazard Information | Back Directory | [Description]
Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors.1 CAY10408 is a free acid, 2-series analog of butaprost. It is the less active C-16 epimer compared to the 16(S) isomer, which has the same stereochemistry as butaprost. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.2 Since the majority of reports related to butaprost utilize the methyl ester derivative,3,4 it may be some time before the precise pharmacology of the free acid compounds, like CAY10408, is reported. | [Uses]
EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC50 of 43 nM[1]. | [in vivo]
EP2 receptor agonist 4 (0-300 μg/kg, i.v.) causes hypotension and inhibits uterine motility in a dose-dependent manner in pregnant rats[1]. | Animal Model: | Pregnant rats[1] | | Dosage: | 0-300 μg/kg | | Administration: | i.v. | | Result: | Induced uterine motility in a dose-dependent manner. |
| [IC 50]
EP2: 43 nM (EC50) | [References]
1. Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells Br. J. Pharmacol. 122(2),217-224(1997).
2. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein Br. J. Pharmacol. 105,817-824(1992).
3. Regan, J.W., Bailey, T.J., Pepperl, D.J., et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype Mol. Pharmacol. 46(2),213-220(1994).
4. Talpain, E., Armstrong, R.A., Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils Br. J. Pharmacol. 114(7),1459-1465(1995). |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
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