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2123482-78-8

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2123482-78-8 Structure

2123482-78-8 Structure
IdentificationBack Directory
[Name]

Tetrazine-SS-Biotin
[CAS]

2123482-78-8
[Synonyms]

Tetrazine-SS-Biotin
[Molecular Formula]

C24H32N8O3S3
[MDL Number]

MFCD34470132
[MOL File]

2123482-78-8.mol
[Molecular Weight]

576.76
Chemical PropertiesBack Directory
[density ]

1.323±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

13.90±0.40(Predicted)
[color ]

Pale purple to light pink
Hazard InformationBack Directory
[Uses]

Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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