2123482-78-8

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2123482-78-8 Structure

Identification	Back Directory
[Name] Tetrazine-SS-Biotin
[CAS] 2123482-78-8
[Synonyms] Tetrazine-SS-Biotin
[Molecular Formula] C24H32N8O3S3
[MDL Number] MFCD34470132
[MOL File] 2123482-78-8.mol
[Molecular Weight] 576.76

Chemical Properties	Back Directory
[density ] 1.323±0.06 g/cm3(Predicted)
[form ] Solid
[pka] 13.90±0.40(Predicted)
[color ] Pale purple to light pink

Hazard Information	Back Directory
[Uses] Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

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