| Identification | Back Directory | [Name]
Allosteric WNK Kinase Inhibitor , | [CAS]
2123489-30-3 | [Synonyms]
WNK-IN-11
ALLOSTERIC WNK KINASE INHIBITOR
Allosteric WNK Kinase Inhibitor ,
WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3
(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone
Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]- | [Molecular Formula]
C21H21Cl2N5OS | [MOL File]
2123489-30-3.mol | [Molecular Weight]
462.4 |
| Chemical Properties | Back Directory | [Boiling point ]
641.1±65.0 °C(Predicted) | [density ]
1.407±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml | [form ]
A crystalline solid | [pka]
5.52±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. | [storage]
Store at -20°C | [References]
[1] Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. DOI:10.1021/acs.jmedchem.7b00708 |
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