| Identification | Back Directory | [Name]
CLK1-IN-1 | [CAS]
2123491-32-5 | [Synonyms]
CLK1-IN-1
CLK1 inhibitor 1
CLK1IN1,CLK1 IN 1,CLK-1-IN-1
1H-1,2,3-Triazolo[4,5-c]quinoline, 8-(5-benzoxazolyl)-1-[(1S)-1-(4-fluorophenyl)ethyl]- | [Molecular Formula]
C24H16FN5O | [MDL Number]
MFCD31692336 | [MOL File]
2123491-32-5.mol | [Molecular Weight]
409.42 |
| Chemical Properties | Back Directory | [Boiling point ]
641.5±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (122.12 mM) | [form ]
Solid | [pka]
4.85±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CLK1-IN-1 is a potent and selective of Cdc2-like kinase 1 (CLK1) inhibitor, with an IC50 of 2 nM. | [in vivo]
APAP exposure results in severe liver injury, and treatment with CLK1-IN-1 (ip, 30 mg/kg) imparts a significant hepatoprotective effect. The results show that treatment with CLK1-IN-1 decreases serum ALT and AST levels significantly such that both marker enzymes return to normal levels[1]. | [IC 50]
CLK1: 2 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Sun QZ, et al. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem. 2017 Jul 27;60(14):6337-6352. DOI:10.1021/acs.jmedchem.7b00665 |
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https://www.weikeqi-biotech.com/ |
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