| Identification | Back Directory | [Name]
2-Amino-3-bromo-6-chloropyrazine | [CAS]
212779-21-0 | [Synonyms]
104365
2-Amino-3-bromo-6-chL
3-Bromo-6-chloro-2-pyrazinamine
2-Amino-3-bromo-6-chloropyrazine
2-PyrazinaMine, 3-broMo-6-chloro-
3-Bromo-6-chloro-pyrazin-2-ylamine
2-Amino-3-bromo-6-chloropyrazine ISO 9001：2015 REACH | [Molecular Formula]
C4H3BrClN3 | [MDL Number]
MFCD11044158 | [MOL File]
212779-21-0.mol | [Molecular Weight]
208.446 |
| Chemical Properties | Back Directory | [Boiling point ]
299.5±35.0 °C(Predicted) | [density ]
1.960 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
0.05±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [InChI]
InChI=1S/C4H3BrClN3/c5-3-4(7)9-2(6)1-8-3/h1H,(H2,7,9) | [InChIKey]
BOLCKGGORFPPJC-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(Cl)=CN=C1Br |
| Hazard Information | Back Directory | [Uses]
2-amino-3-bromo-6-chloropyrazine has essential applications in the pharmaceutical industry and is an important intermediate for synthesizing an anti-tumor medicament SHP2 inhibitor. | [Preparation]
Currently, in thepreparing 2-amino-3-bromo-6-chloropyrazine, the 2-amino-6-chloropyrazine is mainly obtained by a one-step bromination reaction. According to the method, bromine is mainly positioned at an amino para position due to the activation effect of amino; generated byproducts are mainly 2-bromo-3-chloro-5-aminopyrazine and partial dibromo byproduct 2-amino-3, 5-dibromo-6-chloropyrazine, the product 2-amino-3-bromo-6-chloro is less, the yield is low. A process for preparing 2-amino-3-bromo-6-chloropyrazine uses 3-aminopyrazine-2-carboxylate as raw material and includes such steps as chlorination, diazotization bromination, ester hydrolysis, carboxyl rearrangement and removing tert-butyloxycarbonyl.
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
ZEROSCHEM.CO.,LTD.
|
| Telephone: |
10-61256048 13810278579; |
| Website: |
http://www.zeroschem.com |
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