| Identification | Back Directory | [Name]
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate | [CAS]
2127875-65-2 | [Synonyms]
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate | [Molecular Formula]
C5H12O3S2 | [MDL Number]
MFCD32701927 | [MOL File]
2127875-65-2.mol | [Molecular Weight]
184.27 |
| Chemical Properties | Back Directory | [Boiling point ]
348.6±25.0 °C(Predicted) | [density ]
1.283±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
14.03±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31. DOI:10.1002/cmdc.201900497 |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|