| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 1-(2-bromophenyl)-5-methyl-N-2-quinolinyl- | [CAS]
2131223-85-1 | [Synonyms]
YW2065
1H-Pyrazole-4-carboxamide, 1-(2-bromophenyl)-5-methyl-N-2-quinolinyl- | [Molecular Formula]
C20H15BrN4O | [MOL File]
2131223-85-1.mol | [Molecular Weight]
407.26 |
| Chemical Properties | Back Directory | [Boiling point ]
515.9±50.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.51±0.43(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation[1]. | [References]
[1] Yang W, et, al. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62(24):11151-11164. DOI:10.1021/acs.jmedchem.9b01252 |
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