| Identification | Back Directory | [Name]
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- | [CAS]
2133001-88-2 | [Synonyms]
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- | [Molecular Formula]
C30H29N7O3 | [MOL File]
2133001-88-2.mol | [Molecular Weight]
535.6 |
| Chemical Properties | Back Directory | [density ]
1.340±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
12.88±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
FMF-03-145-1 shows doese dependent inhibition of pAurora A (Aurora A substrate) and pH3 S10 (Aurora B substrate) in HCT116 cells. FMF-03-145-1 effects on the cell cycle are consistent with selective on-target inhibition. | [Uses]
Aurora kinase inhibitor-8 is a highly selective inhibitor of the Aurora kinases. | [storage]
4°C, away from moisture and light | [References]
[1] Ferguson FM, et al. Characterization of a highly selective inhibitor of the Aurora kinases. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4405-4408. DOI:10.1016/j.bmcl.2017.08.016 |
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