| Identification | Back Directory | [Name]
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[(2E)-3-(4-fluorophenyl)-2-propen-1-yl]amino]-, (3R,4R,5S)- | [CAS]
2133818-85-4 | [Synonyms]
Influenza virus-IN-4
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[(2E)-3-(4-fluorophenyl)-2-propen-1-yl]amino]-, (3R,4R,5S)- | [Molecular Formula]
C23H31FN2O4 | [MOL File]
2133818-85-4.mol | [Molecular Weight]
418.5 |
| Hazard Information | Back Directory | [Uses]
Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 μM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 μM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1]. | [References]
[1] Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147. DOI:10.1016/j.ejmech.2020.112147 |
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