| Identification | Back Directory | [Name]
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
| [CAS]
213473-00-8 | [Synonyms]
4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine
Benzoicacid,5-acetyl-3-hydroxy-,methylester
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, 10 mM in DMSO | [Molecular Formula]
C12H9BrN4 | [MDL Number]
MFCD22552582 | [MOL File]
213473-00-8.mol | [Molecular Weight]
289.13 |
| Chemical Properties | Back Directory | [Melting point ]
103-106 °C | [Boiling point ]
594.4±60.0 °C(Predicted) | [density ]
1.680±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
14.31±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation[1]. | [References]
[1] Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3 |
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| Company Name: |
DebyeTec.com Inc.
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| Tel: |
18086626237 15327221536; |
| Website: |
https://www.debyetec.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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