| Identification | Back Directory | [Name]
4(1H)-Pyrimidinone, 1-(2,6-dimethoxyphenyl)-2-(ethoxymethyl)-6-hydroxy-5-[[(3R)-3-phenyl-1-pyrrolidinyl]carbonyl]- | [CAS]
2135514-20-2 | [Synonyms]
APJ receptor agonist 5
4(1H)-Pyrimidinone, 1-(2,6-dimethoxyphenyl)-2-(ethoxymethyl)-6-hydroxy-5-[[(3R)-3-phenyl-1-pyrrolidinyl]carbonyl]- | [Molecular Formula]
C26H29N3O6 | [MOL File]
2135514-20-2.mol | [Molecular Weight]
479.52 |
| Hazard Information | Back Directory | [Uses]
APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1]. | [References]
[1] Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113. DOI:10.1021/acs.jmedchem.1c01504 |
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Biorbyt Ltd.
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