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2138321-18-1

2138321-18-1 Structure

2138321-18-1 Structure
IdentificationBack Directory
[Name]

proMMP9-IN-3c
[CAS]

2138321-18-1
[Synonyms]

proMMP9-IN-3c
[Molecular Formula]

C18H20FN3O2S
[MOL File]

2138321-18-1.mol
[Molecular Weight]

361.43
Chemical PropertiesBack Directory
[density ]

1.37±0.1 g/cm3(Predicted)
[pka]

13.68±0.70(Predicted)
Hazard InformationBack Directory
[Description]

ProMMP-9 inhibitor-3c is a potent and specific proMMP-9 inhibitor which disrupts f MMP-9 homodimerization and prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR.
[Uses]

proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX)[1].
[References]

[1] Alford VM, et al. Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. DOI:10.1021/acschembio.7b00758
2138321-18-1 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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