| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[1,3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]- | [CAS]
2138441-30-0 | [Synonyms]
3-(4-(5-hydroxypent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-[1,3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]- | [Molecular Formula]
C18H18N2O4 | [MOL File]
2138441-30-0.mol | [Molecular Weight]
326.35 |
| Chemical Properties | Back Directory | [Boiling point ]
663.6±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
10.67±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
3-(4-(5-Hydroxypent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (Compound 15c) is an important intermediate in the synthesis of RET Degrader[1]. | [References]
[1] Hualong M, et al. Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J Med Chem. 2025 Jan 7. DOI:10.1021/acs.jmedchem.4c01889 |
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